TABLE 1.
Mcp-1 polymorphisms
| Polymorphism (amino acid)
|
|||||
|---|---|---|---|---|---|
| Region | Position | Codon | NZW/OlaHsd (108 ± 1) | CAST/Ei (188 ± 3) | SJL/J (122 ± 1) |
| 5′-UTR | 81,851,811 | — | C | T | C |
| 81,851,812–81,851,817 | — | NC | ACCAGC Del | ACCAGC Ins | |
| Exon 1 | 81,851,873 | 6 | T (Met) | C (Thr) | T (Met) |
| 81,851,887 | 11 | C | C | T | |
| Exon 2 | 81,852,688 | 29 | C | C | T |
| 81,852,742 | 47 | G | A | G | |
| 81,852,749 | 50 | A (Ser) | G (Gly) | G (Gly) | |
| Exon 3 | 81,853,194 | 90 | C | T | C |
| 81,853,199 | 91 | T | C | T | |
| 81,853,201 | 92 | G (Arg) | G (Arg) | A (Gln) | |
Numbering is based on genome sequence NCBI Build 36 (NM_011333). Prion disease incubation times are shown for each strain following intracerebral inoculation of Chandler/RML prions ± SEM (Lloyd and Collinge 2005). Amino acids are shown only for nonsynonomous polymorphisms. NC, no change when compared to database sequence for Mcp-1; Del, deletion; Ins, insertion.