Figure 2.—

β-Catenin is detectible in the nucleus of neoplastic cells within the pancreas. The pancreas was removed from a B6 Apc^Min/+ p53^{tm1TyjJ/tm1TyjJ} mouse (A–C) or a 129 Apc^Min/+ p53^BCM/BCM mouse (D–F and G–I) at 100 days of age, embedded in paraffin, and sectioned. Every 10th slide was stained with hematoxylin and eosin (A, D, and G). Adenomas (A and D) and adenocarcinomas (G) were apparent. The levels of β-catenin antigens (B, E, and H) within cells were determined by immunofluorescence microscopy. Nuclei were counterstained with DAPI (C, F, and I). Bars, 200 μm.