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The development of three distinct neoplasms in the laboratory mouse is affected by Apc, p21, p53, and modifiers that are polymorphic between 129 and B6. The tumor suppressor genes and polymorphic modifiers can have a partial (dashed line) or complete (solid line) effect. Whether modifiers act in a recessive fashion to resist (r) or a dominant fashion to enhance susceptibility (S) was ascertained by analyzing two parental strains and their F1 hybrid.
