TABLE 2.
Effect of p21 and genetic background on the development of neoplasms in ApcMin/+ mice
| Intestinal tumor count,a mean ± SD (no. of mice)
|
Desmoid fibroma count, mean ± SD (no. of mice)
|
Pancreatic tumors, tumor bearing/totalb
|
||||
|---|---|---|---|---|---|---|
| Genotype | Mixed backgroundc | 129 | Mixed backgroundc | 129 | Mixed backgroundc | 129 |
| ApcMin/+p21+/+ | 59 ± 30 (7) | 54 ± 34 (11) | 0 ± 0 (4) | 2 ± 3 (10) | 0/7 | 0/11 |
| ApcMin/+p21+/− | 120 ± 76 (20) | 97 ± 51 (26) | 2 ± 3 (9) | 3 ± 3 (25) | 0/20 | 0/26 |
| ApcMin/+p21−/− | 178 ± 136 (16) | 101 ± 39 (12) | 1 ± 2 (9) | 4 ± 4 (12) | 0/16 | 0/12 |
| Apc+/+p21−/− | 0 ± 0 (10) | 0 ± 0 (8) | 0 ± 0 (7) | 0 ± 0 (8) | 0/10 | 0/8 |
a
Total tract.
b
Mice were scored as tumor bearing if a tumor was detected during necropsy at 90–100 days of age.
c
Heterozygous p21+/− progeny of the cross (B6 × 129)F2 p21+/− × 129 ApcMin/+ were intercrossed to generate these mice.