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Spindle and chromosome organization in stage 14 oocytes. Tubulin (green) and DNA (blue and inserts) were stained in mature stage 14 oocytes. A normal bipolar spindle in wild type (A) compared to mei-381 mutant oocytes showing (B and C) disorganized karyosomes where chromosomes are not symmetrically arranged in a karyosome or (D) a monopolar spindle. Bar, 10 μm.
