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. Author manuscript; available in PMC: 2008 Sep 14.
Published in final edited form as: J Am Chem Soc. 2008 Feb 14;130(10):3053–3064. doi: 10.1021/ja076529e

Figure 7.

Figure 7

Possible catalytic role of Mg2+ in the full-length hammerhead ribozyme. The C-site in the pre-reactive state involves binding at the N7 of G10.1 and the A9 pro-R phosphate oxygen. Activation of the 2′OH may occur through interactions with G12, the proposed general base. Migration from the C-site to a bridging position between A9 and the scissile phosphate occurs; in proceeding to the transition state the Mg2+ acquires additional interaction with the O5′leaving group and the 2′OH of G8, the implicated general acid.