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Amide H/2H exchange at the autolysis loop and Na+-binding site of thrombin. A) On-exchange into residues 166-180 (peptide MH+ 1619.87) of thrombin (●) and prethrombin-2 (■). B) On-exchange into residues 166-180 (peptide MH+ 1619.87) of thrombin (●) and prothrombin (▲). C) On-exchange into residues 260-275 (peptide MH+ 1788.80) of thrombin (●) and prethrombin-2 (■).
