Table 1.
Apparent molecular weights (Mw) and hydrodynamic diameters (Dh) of the GalNAc-ligated and unligated polymers.
| unligated Mw (g/mol)[a] | ligated Mw (g/mol)[b] | unligated Dh (nm) | ligated Dh (nm)[d] | calcd length[e] | % extension | |
|---|---|---|---|---|---|---|
| 5 | 18330 | 72530 | 1.9[c] | 54.0 | 66.8 | 81 |
| 6 | 32500 | 102880 | 2.0[c] | 54.7 | 95.8 | 57 |
| 7 | 29690 | 72530 | 2.1[d] | 65.0 | 78.5 | 83 |
[a]
Molecular weights were determined by GPC based on a polystyrene standard curve.
[b]
Molecular weights were determined by GPC based on a polysaccharide standard curve.
[c]
Hydrodynamic radii were measured in THF.
[d]
Hydrodynamic radii were measured in water.
[e]
Values were calculated for the fully extended polymers based on their apparent molecular weights, using MM2 force field-based molecular mechanics predictions.