Table 2. Summary of protein deficiencies leading to an increase in radial formation.

Loss of function or siRNA depletion of proteins listed here causes increased radial formation either spontaneously, following ICL-damage, or both. Five of these have been shown in the depletions in this manuscript. BLM is Bloom syndrome protein. DNA-PK is for the mouse Prkdc protein, the catalytic subunit of DNA-dependent protein kinase.

Protein deficiency causing ICL-induced radial increase
FA proteins1
BLM5
RAD512*
RAD522
LIG42
MRE112
Ku702
BRCA13
BRCA23
SNM14
ERCC16
DNA-PK7

¹(Schroeder et al. 1964; reviewed in D’Andrea and Grompe 2003)

²shown in this manuscript.

³(Bruun et al. 2003).

⁴(Hemphill et al. 2008).

⁵(German 1997).

⁶(Niedernhofer et al. 2004).

⁷(Houghtaling et al. 2005).

^*spontaneous radials without clastogen exposure.