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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Hepatology. 2008 Sep;48(3):732–740. doi: 10.1002/hep.22422

Fig. 2.

Fig. 2

HCV sequence analyses. (A) Distribution of amino acid substitutions in patient serum- (CH10273) and JFH-1cc- (CH10274) inoculated chimpanzees. Positions of amino acid substitutions are indicated as vertical bars, and the mutated amino acids are shown at the bottom of each panel. The amino acid numbers correspond to the JFH-1 sequence. (B) HVR-1 populations in patient serum (inoculum) and chimpanzees. HVR-1 sequence in patient serum has been reported previously (6). HVR-1 sequences determined by direct sequencing (Direct) or cloning and sequencing (Cloning)(10 clones at each time point) in each animal are shown. Investigated time points (#1, 2 and 3) are indicated in Fig. 1. Identical amino acids are indicated as dots.