Table 3.
Association of infant outcomes with low neutrophil count (<1000/ μL.). Entries are odds ratios with 95% confidence intervals or difference with 95% confidence interval. Infants with WBC ≥ 12, 000 are excluded.
| White count/μL.: | Overall1 OR 95% CI | <5000 OR 95% CI | 5000-<7000 OR 95% CI | 7000-<12000 OR 95% CI |
|---|---|---|---|---|
| SNAP-II unadjusted | 6.9***
4.2- 9.7 |
5.7**
1.9- 9.6 |
9.8***
4.6- 15 |
6.3
-0.2- 13 |
| SNAP-II adjusted2 | 3.6**
1.4- 5.8 |
2.3
-0.9- 5.4 |
6.3**
2.0- 11 |
4.1
-1.2- 9.5 |
| ≥Moderate BPD unadjusted | 1.9**
1.1-3.1 |
1.9*
1.1- 3.4 |
2.3*
1.0- 5.1 |
1.4
0.5- 3.9 |
| Severe BPD unadjusted | 1.8*
1.0-3.3 |
1.2
0.6- 2.8 |
3.2*
1.2- 8.3 |
1.6
0.4- 5.9 |
| BPD across levels adjusted2 | 1.7*
1.1-2.7 |
1.7
0.9- 3.1 |
1.9
0.8- 4.8 |
1.6
0.5- 5.0 |
| BPD across levels adjusted3 | 1.7*
1.0-2.7 |
1.5
0.8- 2.8 |
2.0
0.8- 4.9 |
1.7
0.6- 5.3 |
| Any IVH unadjusted | 1.5
1.0-2.2 |
1.9
1.0- 3.5 |
1.6
0.8- 3.4 |
0.7
0.3- 2.0 |
| ≥ grade 2 IVH unadjusted | 2.1**
1.2-3.6 |
2.3*
1.0-5.2 |
2.9*
1.2-6.8 |
1. 2
0.4-3.7 |
| ≥ grade 3 IVH unadjusted | 2.5**
1.3-4-7 |
2.3
0.9- 5.9 |
7.3***
2.3- 23 |
0.8
0.2- 3.8 |
| grade 4 IVH unadjusted | 2.6*
1.2-5.8 |
4.0
0.9- 18 |
5.4*
1.3- 23 |
0.7
0.09- 5.3 |
| IVH across grades 2 to 4 adjusted2 | 2.2**
1.3-3.8 |
2.7*
1.1- 6.7 |
3.0*
1.2- 7.4 |
1.2
0.4- 4.1 |
| IVH across grades 2 to 4 adjusted3 | 2.2
1.3-3.8 |
2.6*
1.0-6.6 |
2.9*
1.2- 7.1 |
1.2
0.4- 4.0 |
***
p<0.001
**
p<0.01
*
p<0.05 for significance of association with low neutrophil count.
1
Overall odds ratios, and SNAP-II difference are adjusted for white count categories included in addition to other variables.
2
Adjusted for birth weight, gestational age, sex and antenatal steroids.
3
Adjusted for birth weight, gestational age, sex and sepsis during NICU stay.