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. Author manuscript; available in PMC: 2008 Sep 15.
Published in final edited form as: J Am Chem Soc. 2007 Feb 7;129(5):1312–1320. doi: 10.1021/ja066780e

Figure 5.

Figure 5

Schematic diagram depicting the strategy for the measurement of Kdintra for HCA**-SSEGnSA using the observed dissociation constant (Kdcomp,Ethox) for a competing ligand, Ethox (shown as black triangle). For this thermodynamic cycle, Kdintra = KdEthox / Kdcomp,Ethox (eq 5).