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. 1988 Mar;62(3):768–775. doi: 10.1128/jvi.62.3.768-775.1988

Failure of simian virus 40 small t antigen to disorganize actin cables in nonpermissive cell lines.

B Phillips 1, K Rundell 1
PMCID: PMC253630  PMID: 2828672

Abstract

Mouse C3H 10T1/2 cell lines expressing the simian virus 40 (SV40) small t antigen were obtained by cotransfection of pSV2neo and plasmids which encode small t. Cell lines derived from two plasmids which encode small t in the absence of stable deletion fragments of the large T antigen were morphologically normal and grew to slightly higher saturation densities in low serum than control cell lines. Unexpectedly, the clones had highly organized actin cables, as did parental 10T1/2 cells infected with wild-type SV40. These observations and comparisons of rat F111 cells infected with either polyomavirus or SV40 suggest that the SV40 small t antigen does not directly affect cytoskeletal organization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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