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. Author manuscript; available in PMC: 2008 Sep 15.
Published in final edited form as: Hepatology. 2008 Apr;47(4):1211–1222. doi: 10.1002/hep.22202

Fig. 8. SULF2 mRNA expression is increased in approximately 60% of HCCs.

Fig. 8

High SULF2 is associated with decreased patient survival and more rapid recurrence after surgical resection. (A) Results of oligonucleotide microarray analysis performed on 139 pairs of tumor and benign samples from primary HCCs, plotted as a log 2–fold change of SULF2 mRNA expression, tumor over benign. (B,C) Survival and tumor recurrence after surgical resection in 139 patients with HCCs. Differences between the Kaplan-Meier curves of patients with up-regulated expression of SULF2 and those with down-regulated expression of SULF2 with the log rank test. (D) Survival after surgical resection in the 20 patients with the highest tumor/benign SULF2 mRNA expression and in the 20 patients with the lowest tumor/benign SULF2 mRNA expression. Increased SULF2 is associated with a worse survival and more rapid recurrence after surgical resection of the primary tumor.