Table 4.

Changes in Retinal Thickening from Baseline to 12 Months in the Two Treatment Groups Stratified by Degree of Thickening at Baseline

	mETDRS Group		MMG Group
	N	mean ± SD	N	mean ± SD
Change in Central Subfield Thickening at 12 Months*
Total	106	−88 ± 138	107	−49 ± 122
Baseline Central Subfield Thickness*
250–349 microns	62	−22 ± 62	53	−7 ± 79
350–449 microns	22	−75 ± 84	32	−74 ± 100
≥ 450 microns	22	−285 ± 155	22	−112 ± 189
P-value for interaction†	<0.001‡ / 0.04§
Change in Weighted Inner Zone Thickening at 12 Months
Total	123	−42 ± 83	127	−28 ± 67
Baseline Weighted Inner Zone Thickness
250–349 microns	88	−14 ± 42	81	−12 ± 52
350–449 microns	22	−55 ± 60	36	−49 ± 56
≥ 450 microns	13	−208 ± 120	9	−92 ± 146
P-value for interaction†	<0.001‡ / 0.04§
Change in Maximum Retinal Thickening at 12 Months||
Total	139	−66 ± 123	134	−39 ± 114
Baseline Maximum Retinal Thickening
0 – 99 microns	63	−4 ± 53	49	+17 ± 86
100 – 199 microns	38	−51 ± 65	43	−55 ± 73
≥ 200 microns	38	−184 ± 162	42	−89 ± 147
P-value for interaction†	<0.001‡ / 0.24§
Change in Retinal Volume at 12 Months
Total	107	−0.8 ± 1.4	91	−0.4 ± 1.3
Baseline Retinal Volume
< 8 mm3	54	−0.2 ± 0.5	33	−0.4 ± 0.4
8 – < 9 mm3	29	−0.6 ± 0.8	29	0.2 ± 1.5
≥ 9 mm3	24	−2.3 ± 2.1	29	−1.1 ± 1.4
P-value for interaction†	0.03‡ / 0.38§

^*Central subfield thickening includes only eyes with central subfield thickness = 250 microns at baseline

^†Statistical test for whether treatment group difference varies according to baseline OCT measurement. P-value obtained using repeated measures least squares regression models adjusting for baseline values and accounting for the correlated data from subjects with 2 study eyes.

^‡P-value based on the absolute change from baseline to follow up

^§P-value based on the log of the ratio of follow up to baseline

^||Maximum of central and 4 inner subfields

Note one eye in the MMG group had baseline Weighted Inner Zone thickness < 250 microns