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. 2008 Apr 10;586(Pt 11):2807–2815. doi: 10.1113/jphysiol.2008.151449

Table 2.

Blood gas variables during exercise with and without β 1 + 2 adrenergic blockade

Exercise

Rest 60 W 120 W 180 W 210 W 240 W Recovery
CO2 (mm)
 Control a 9.0 ± 0.3 8.9 ± 0.6 9.2 ± 0.6 9.4 ± 0.8 9.6 ± 0.8* 9.7 ± 0.8* 8.9 ± 0.6
v 5.5 ± 0.6 6.1 ± 0.6 6.2 ± 0.6 6.1 ± 0.8 5.4 ± 1.1 5.4 ± 0.8 5.2 ± 0.8
 Propranolol a 8.9 ± 0.6 8.9 ± 0.6 9.2 ± 0.8 9.5 ± 0.6* 9.8 ± 0.6* 8.8 ± 0.6
v 5.5 ± 0.8 5.8 ± 0.6 5.6 ± 0.6 5.5 ± 0.8 5.5 ± 0.8 5.3 ± 0.8
Inline graphic (%)
 Control a 98.3 ± 0.6 98 ± 0.8 97.5 ± 0.6 97.1 ± 0.8 96.9 ± 0.6 96.8 ± 1.1* 96.7 ± 1.7*
v 66.0 ± 4.5 65.7 ± 2.8 65.8 ± 3.9 58.6 ± 7.4 57.4 ± 7.4* 53.3 ± 8.5* 55.6 ± 5.7*
 Propranolol a 98.0 ± 0.8 97.7 ± 0.8 97.7 ± 0.8 97.5 ± 0.6 97.6 ± 1.1 97.2 ± 1.7
v 60.5 ± 6.8 63.2 ± 5.1 60.8 ± 4.5 56.7 ± 7.6 51.2 ± 8.2* 59.4 ± 7.6
Hb (mm)
 Control a 8.7 ± 0.6 9.0 ± 0.6* 9.4 ± 0.6* 9.6 ± 0.8* 9.9 ± 0.8* 10.0 ± 0.8* 9.2 ± 0.6*
v 8.8 ± 0.6 9.1 ± 0.6 9.4 ± 0.6 9.8 ± 0.8 9.3 ± 1.7 10.0 ± 0.6 9.2 ± 0.6
 Propranolol a 8.8 ± 0.8 9.0 ± 0.6* 9.3 ± 0.6* 9.7 ± 0.6* 9.7 ± 0.6* 9.0 ± 0.6*
v 8.8 ± 0.6 9.1 ± 0.6 9.4 ± 0.6* 9.8 ± 0.6* 9.8 ± 0.6* 9.1 ± 0.6*
Inline graphic (kPa)
 Control a 13.4 ± 0.8 13.2 ± 0.8 12.7 ± 0.8 13.1 ± 1.7 13.1 ± 1.1 13.3 ± 2.3 12.6 ± 1.7
v 4.9 ± 0.3 4.9 ± 0.3 5.0 ± 0.3 4.7 ± 0.3 4.5 ± 0.3 4.5 ± 0.3* 4.4 ± 0.3*
 Propranolol a 13.1 ± 1.3 12.6 ± 0.8 12.6 ± 1.1 12.7 ± 0.6 13.0 ± 0.8 12.2 ± 1.9
v 4.5 ± 0.6 4.7 ± 0.6 4.6 ± 0.3 4.5 ± 0.6 4.1 ± 0.6 4.6 ± 0.6
Inline graphic (kPa)
 Control a 5.5 ± 0.3 5.6 ± 0.3 5.5 ± 0.3 5.0 ± 0.6* 4.4 ± 0.6* 3.9 ± 0.3* 4.7 ± 0.6*
v 7.0 ± 0.3 7.1 ± 0.3 6.9 ± 0.3 6.5 ± 0.6* 6.3 ± 0.8* 6.3 ± 0.3* 6.5 ± 0.3
 Propranolol a 5.5 ± 0.6 5.6 ± 0.3 5.5 ± 0.3 4.1 ± 0.3* 4.6 ± 0.6* 5.0 ± 0.6
v 7.1 ± 0.3 7.1 ± 0.3 7.1 ± 0.3 6.8 ± 0.3 6.6 ± 0.3* 6.7 ± 0.3*

Blood gas variables during exercise with and without non-selective β-blockade. CO2, CO2 concentration; Inline graphic, O2 saturation; Hb, haemoglobin concentration; Inline graphic, O2 partial pressure; Inline graphic, carbon dioxide partial pressure.

*

Different from rest (P < 0.05);

different from control exercise (P < 0.05). Values are means ± s.d.