Fig. 1.

Grey matter volume decreases in probands with enuresis compared with probands without enuresis. This figure depicts the statistical main effects of decreased regional grey matter volume comparing probands with a history of childhood enuresis to those without a history. The unthresholded VBM results are overlaid on an analysis of functional neuro-images (AFNI) pial surface and colour coded for the statistical t-score. The central figure is the frontal view and the other figures, from left to right, are the left lateral, left medial, right medial and right lateral hemispheric surface views. The most significant cluster of decreased grey matter volume in probands with enuresis is in the right superior frontal gyrus, BA 9 (coordinates x = 22, y = 51, z = 39, P < 0.001). Other clusters that were statistically significant are listed in Table 3.