Table 2.
Quantitation of wild-type dystrophin transcript in cxmd recipient muscle injected with fresh cellsa
| Sample | Relative level of dystrophin expression | P value |
|---|---|---|
| G289 | ||
| Preinjection | 0.00035 ± 0.00009 | — |
| 10 Weeks | 6.48 ± 0.34 | 0.00069 |
| G604 | ||
| Preinjection | 0.0019 ± 0.0001 | — |
| 4 Weeks | 1.29 ± 0.25 | 0.0031 |
| 24 Weeks | 1.32 ± 0.46 | 0.010 |
| WT | 100 | — |
a
RNA isolated from muscle biopsy cryosections was analyzed by quantitative reverse transcriptase-PCR. Values represent the average level of wild-type dystrophin transcript present in muscle, relative to normal donor, and normalized to β-actin expression (±SD). The level of dystrophin expression in the injected samples was compared to the preinjection sample using the Student's t-test to obtain the P value.