Table 1. Characteristics of the Study Population (N=174) and Univariate Analysis of Factors Predicting Disclosure of Genetic Test Results to Any Family Members Beyond 1st Degree.
| All Subjects who had Genetic Testing
(N=174) |
Subject Disclosure to Family Members | |||
|---|---|---|---|---|
| Told Beyond 1st Degree
(N=109)* |
Did Not Tell Beyond 1st Degree
(N=53)* |
|||
| Frequency (%) | Frequency (%) | Frequency (%) | p-value† | |
| Mean Age (Range) | 46.7 (18-79) | 45.96 | 45.26 | 0.73 |
| Gender | 0.20 | |||
| Male | 52 (29.9) | 28 (59.6) | 19 (40.4) | |
| Female | 122 (70.1) | 81 (70.4) | 34 (29.6) | |
| Race | 0.15 | |||
| White | 157 (90.8) | 96 (65.3) | 51 (34.7) | |
| Non-white | 16 (9.3) | 13 (86.7) | 2 (13.3) | |
| Unknown/missing | 1 (--) | |||
| Education | 0.72 | |||
| Less than college grad | 53 (31.0) | 34 (69.4) | 15 (30.6) | |
| At least college grad | 118 (69.0) | 73 (65.8) | 38 (34.2) | |
| Unknown/missing | 3 (--) | 2 (--) | -- (--) | |
| Marital Status | 1.00 | |||
| Married | 132 (75.9) | 81 (66.9) | 40 (33.1) | |
| Not Married | 38 (21.8) | 26 (68.4) | 12 (31.6) | |
| Unknown/missing | 4 (2.3) | 2 (--) | 1 (--) | |
| Cancer Diagnosis | 0.50 | |||
| Yes | 106 (60.9) | 66 (69.5) | 29 (30.5) | |
| No | 68 (39.1) | 43 (64.2) | 24 (35.8) | |
| Test Results | 0.03 | |||
| Positive | 104 (59.8) | 73 (75.3) | 24 (24.7) | |
| Indeterminate | 47 (27.0) | 24 (57.1) | 18 (42.9) | |
| True negative | 23 (13.2) | 12 (52.2) | 11 (47.8) | |
| Cancer Worry | 0.55 | |||
| Low | 58 (33.5) | 35 (66.0) | 18 (34.0) | |
| Moderate | 65 (37.6) | 44 (72.1) | 17 (27.9) | |
| High | 50 (28.9) | 30 (62.5) | 18 (37.5) | |
| Unknown/missing | 1 (--) | |||
| Prior Genetic Testing in Family | 1.00 | |||
| Yes | 128 (73.6) | 82 (67.2) | 40 (32.8) | |
| No | 39 (22.4) | 24 (68.6) | 11 (31.4) | |
| Don't Know | 7 (4.0) | 3 (--) | 2 (--) | |
| Mutation Previously identified in Family | 0.48 | |||
| Yes | 113 (64.9) | 75 (69.4) | 33 (30.6) | |
| No | 61 (35.1) | 34 (63.0) | 20 (37.0) | |
| History of Lynch Syndrome cancer in 1 or more relatives | 1.00 | |||
| Yes | 155 (89.1) | 98 (67.1) | 48 (32.9) | |
| No | 19 (10.9) | 11 (68.8) | 5 (31.2) | |
| Mean number of relatives with Lynch Syndrome Cancers | 3.71 [+/- 2.0] | 4.04 [+/- 2.1] | 3.38 [+/- 1.8] | 0.05 |
| Subjects With Children | 0.72 | |||
| Yes | 122 (70.1) | 76 (68.5) | 35 (31.5) | |
| No | 52 (29.9) | 33 (64.7) | 18 (35.3) | |
| Ever evaluated in a genetics/ high risk clinic | 0.78 | |||
| Yes | 154 (89.0) | 98 (67.6) | 47 (32.4) | |
| No | 19 (11.0) | 10 (62.5) | 6 (37.5) | |
| Unknown/missing | 1 (--) | 1 (--) | -- (--) | |
*
162 Subjects who indicated they have at least 1 SDR or TDR to tell
†
Comparison between subjects who did and did not tell relatives beyond 1st degree, Fisher's Exact Test used for all categorical variables; t-test used for all continuous variables