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. Author manuscript; available in PMC: 2008 Sep 15.
Published in final edited form as: FEBS J. 2007 Dec 6;275(1):44–58. doi: 10.1111/j.1742-4658.2007.06172.x

Scheme 1. Model structure of human eIF5A with critical amino acid residues.

Scheme 1

The structure of human eIF5A-1 is based on the model (PDB 1FH4) constructed by Facchiano et al. (36). Both the N- and C-terminal domains (in blue and aqua-blue) consist of β-sheet core structures and are connected by a hinge at Asn83-Ile84. The hypusine modification site (Lys 50, in red) is located at an exposed loop (hypusine loop aa46–54) in the basic N-terminal domain. No growth is observed upon Ala substitution of the red and orange colored residues (Lys50, Gly49, Gly52 and Lys55) and slow growth upon Ala substitution of the green colored residues (Lys47, His55, Pro74, Leu91 and Leu101).