Table 1.
Demographics and clinical characteristics of the study population by metabolic syndrome criteria and genotype
|
-MetS |
+MetS |
|||
|---|---|---|---|---|
|
TT (n = 41) |
TG & GG (n = 29) |
TT (n = 45) |
TG & GG (n = 25) |
|
| Age, years | 46±13 | 47±12 | 54±12 | 52±11 |
| Female, n (%) | 24 (59%) | 15 (52%) | 18 (40%) | 16 (64%) |
| Body mass index, kg/m2 | 25±3 | 24±3 | 35±6 | 34±4 |
| Waist circumference, cm | 80±10 | 81±12 | 107±16 | 103±11 |
| Systolic BP, mmHg | 110±9 | 112±11 | 131±16 | 127±17 |
| Diastolic BP, mmHg | 72±7 | 74±8 | 83±8 | 81±9 |
| Triglyceride, mg/dL | 78±24 | 85±29 | 226±102 | 183±69 |
| HDL cholesterol, mg/dL | 60±12 | 64±19 | 41±10 | 41±8 |
| LDL cholesterol, mg/dL | 120±31 | 120±27 | 110±33 | 103±27 |
| Total cholesterol, mg/dL | 196±33 | 201±32 | 195±34 | 181±30* |
| Past medical history and medical therapy, n (%) | ||||
| Hypertension | — | 2 (7) | 30 (67) | 20 (80) |
| Coronary artery disease | — | — | 2 (4) | 3 (12) |
| Type 2 diabetes mellitus | — | 1 (3) | 16 (36) | 15 (60)* |
| Current smoker | 4 (14) | 3 (13) | 4 (16) | 3 (20) |
| Prior smoker | 12 (32) | 6 (23) | 20 (49) | 10 (45) |
| Statin | 1 (2) | 1 (3) | 12 (27) | 11 (44) |
| † | n = 41 | n = 29 | n = 35 | n = 13 |
|---|---|---|---|---|
| Insulin, mU/mL | 5.7±2.7 | 5.2±2.4 | 17.9±13.3 | 15.0±10.2 |
| Glucose, mg/dL | 83±11 | 86±12 | 100±19 | 105±37 |
| HOMA-IR | 1.1±0.7 | 1.1±0.7 | 4.5±3.5 | 3.9±2.7 |
Data are expressed as mean ± standard deviation or number (percentage) of subjects; p values reflect significance after age- and gender-adjustment within each group.
*
p=.05 vs. TT group.
†
Insulin, glucose, and HOMA-IR are in fasting subjects, excluding diabetics receiving insulin or oral hypoglycemic agents.
BP, blood pressure; HDL, high-density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; LDL, low-density lipoprotein; MetS, metabolic syndrome.