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. Author manuscript; available in PMC: 2009 Aug 29.
Published in final edited form as: Neurosci Lett. 2008 Jun 27;441(3):319–322. doi: 10.1016/j.neulet.2008.06.061

Figure 3.

Figure 3

(A) The concentration of Aβ42 in the CM from cultures of Aβ+CHO alone, Aβ+CHO/sub-confluent EC, and Aβ+CHO /confluent EC was determined after 24h, 48h, and 120h of culture. The concentration of Aβ42 was largest in cultures of Aβ+CHO alone and Aβ+CHO/sub-confluent EC at 48h, and much less in the culture of Aβ+CHO/confluent EC at 48h (p<0.005 compared to Aβ+CHO/sub-confluent EC). (B) CM from Aβ42 secreting cells (Aβ+CHO) were collected over 120h, and each sample was further incubated for various times. Fibril formation significantly increased over 48 hours of collection (p<0.001 at 48 hours compared to 24 hours). Prolonged incubation after collection increased fibril formation, especially after 48 hours of collection (p<0.005 compared to no additional incubation time).