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. Author manuscript; available in PMC: 2008 Nov 15.
Published in final edited form as: J Med Chem. 2007 Oct 18;50(23):5780–5789. doi: 10.1021/jm070396q

Figure 2.

Figure 2

Mechanism based inhibition of NQO1 by representative indolequinones. NQO1 activity was assayed following the incubation of indolequinone (100 nM) with rhNQO1 (1 μg) in the absence (solid bars) and presence (striped bars) of 0.2 mM NADH. Incubations (0.5 mL) were performed for 5 min at 32 °C. Results are the mean ± standard deviation of three separate determinations.