Table 2.
Association of invasive cervical cancer with p53 arg/arg genotype1, with various approaches to inter-laboratory disagreements
| Referent category definition1 | Index category (Arg/Arg genotype) definition2 | OR (95% CI) | |
| Crude | Adjusted3 | ||
| Non-stringent | Disagreed | 1.6 (0.6–4.2) | 1.5 (0.5–3.9) |
| All-inclusive | 2.4 (1.2–5.0) | 2.4 (1.1–5.3) | |
| Agreed | 2.6 (1.0–6.9) | 3.4 (1.2–9.9) | |
| Stringent | Disagreed | 2.7 (0.9–8.1) | 2.8 (0.9–8.9) |
| All-inclusive | 4.1 (1.7–10.0) | 5.0 (1.9–13.3) | |
| Agreed | 4.5 (1.5–13.4) | 8.0 (2.3–28.5) | |
1 Non-stringent definition allows inter-laboratory disagreement for the Arg/Pro and the Pro/Pro genotypes; stringent definition includes only genotypes with complete agreement among the three laboratories (adapted from reference 1).
2 Disagreed: includes only subjects with an Arg/Arg genotype determined by at least one laboratory but with different results from the other laboratories; Agreed: includes only Arg/Arg subjects with complete agreement among laboratories; All-inclusive: includes any reported Arg/Arg genotype with or without agreement among laboratories or in isolation
3 OR adjusted for age and race.