Table 1.
Selected genes enriched in α6+/MHCI+ cells compared to α6+/MHCI- cells.
| Factors downregulated in HHFSC | CDC2 (1.7), PRC1 (1.6), RRM2 (2.3), ZWINT (1.1), KPNA2 (1.1), FEN1 (1.1), TOP2A (4.5), TYMS (1), RHEB2 (1.2). |
| Factors downregulated in MHFSC | THBD (1.1), RBMS1 (4.2), MYC (1), ABCD4 (1.8), UGP2 (1.6), IGFBP3 (1.1), WNT3 (3.8), WNT4 (3.6), DSC2 (1.8), HSPA1A (2.4), CKMT1 (1), RORA (2.4), ANXA1 (1.4), ANXA2 (1.8), COL17A1 (2.2), IL6ST (1.7), TGFBR2 (1.3), LGALS7 (1.8), KRT5 (1), KRT15 (1.2), SERPINB2 (1), SERPINB7 (1.8), GPR87 (1.3), TGFBI (1.3), VSNL1 (1.2), CLCA2 (1.7), E48 (2), MKI67 (2), CKS2 (1.1), PRC1 (1.6), HLA-B (2.4), HLA-B39 (2), HLA-C (1.1), HLA-Cw*1701 (2.9), HLA-E (1.6), D6S81E (1.7), CCNB1 (2.2), CCNB2 (1.7), CCND1 (1.3), CCND2 (3.3), CHEK1 (1.7), CDC6 (1.6). |
| TGFβ/BMP-repressed factors | MYC (1), MT1F (1.6), MT1G (1.1), UGP2 (1.6), CCND2 (3.3), KRT15 (1.2), VIL2 (3.3), CKMT1 (1), EHF (2.2), NIBAN (1.7), VAMP8 (3.2), TNNI2 (1.4), KLF4#. |
| WNT-induced factors | MYC (1), CCNB1 (2.2), CCND1 (1.3), CCND2 (3.3), JUN (1), CKS2 (1.1), MKI67 (2), BIRC5 (2.5), TNNT1 (3.5), TNNI2 (1.4), MBNL (1.4), IGFBP3 (1.1), PTTG1 (1.1), EGFR (1.2), EMP1 (2.1), CSPG6 (2.8), CALD1 (1.2), BTEB2 (1.8), DUSP6 (3.5), FOS (2.2), JWA (1.2), HSP70 (1.4), KRT5 (1), GSTM3 (1.3), NCOA3 (1.3), OSF2 (1.1), SDC4 (1), ELF1 (1.6), HMG14 (1), TRA1 (2.3), CDC6 (1.6), DHFR (1.1), ADE2H1 (2), NSAP1 (1.2), MCM4 (3.4), KPNB3 (1.2), KRTHA1 (0.5)#, MYCBP (0.6)#. |
| NF-κB-induced factors | MYC (1), MT1F (1.6), MT1G (1.1), CCND1 (1.3), FTH1 (1.7), IGFBP1 (2), HMG14 (1), AKR1C2 (1), UGCG (1.1), GBP-1 (1.2), ATF3 (3.3), SDC4 (1), PTGS2 (1.3), BMP2 (1.3), DUSP6 (3.5), MGP (1.1), FOS (2.2), MCP-1 (5.4), PIG7 (2), MIF (1.8), PMAIP1 (1.3), LSR68 (3.6), TNFS10 (2.7), HLA-B (2.4), HLA-B39 (2), HLA-C (1.1), HLA-Cw*1701 (2.9), HLA-E (1.6), D6S81E (1.7), HSPB1 (3). |
Functional classification of some of the genes that are selectively upregulated ≥ 2 fold in α6+/MHCI+ cells relative to α6+/MHCI- cells (for the full list see Additional file 1). The numbers shown in parentheses are in log2 scale and are the highest score for that gene. Expression of the genes marked with (#) have been additionally verified (Figure 4).