Table 1.
Genes expressed in developing interneurons linked to neurological disorders
| Gene function | Gene | Human |
Mouse |
||
| Disease | Ref. | Endophenotype | Ref. | ||
| Transcription factors/regulators | Npas3 | Schizophrenia | (Pickard et al. 2005; Pickard et al. 2006) | Impaired prepulse inhibition; Impaired social recognition. | (Erbel-Sieler et al. 2004) |
| Hdac11 | Autism | (Szatmari et al. 2007) | NA | ||
| Cited2 | Autism | (Szatmari et al. 2007) | NA | ||
| Meis1 | Autism | (Szatmari et al. 2007) | NA | ||
| Zfhx1b | Autism; Mental retardation; Epilepsy | (Inlow and Restifo 2004; Dastot-Le Moal et al. 2007; Hoffer et al. 2007) | NA | ||
| Arx | Epilepsy; mental retardation; lissencephaly | (Inlow and Restifo 2004; Kato et al. 2007) | Deficit in interneuron migration. | (Colombo et al. 2007) | |
| Cell surface | Ncam1 | Schizophrenia; Bipolar disorder | (Atz et al. 2007) | Abnormal interneurons; Impaired sensory gating and fear conditioning; Deficient prepulse inhibition; Impaired startle response. | (Pillai-Nair et al. 2005) (Plappert et al. 2005, 2006) |
| Chl1 | Mental retardation | (Frints et al. 2003) | Impaired prepulse inhibition; Impaired acoustic startle response | (Irintchev et al. 2004) | |
| Cntnap4 | Autism | (Sebat et al. 2007) | NA | ||
| Sema3a | Autism | (Szatmari et al. 2007) | NA | ||
| Channels/neurotransmission | Cacnb4 | Autism; epilepsy | (Escayg, De Waard, et al. 2000; Szatmari et al. 2007) | Ataxia; lethargy; seizures. | (Fletcher and Frankel 1999) (Burgess and Noebels 1999a, 1999b) |
| Cacng2 | Schizophrenia; epilepsy | (Sutrala et al. 2007) | Epileptic seizures | (Letts et al. 1998) | |
| Scn1a | Mental retardation; epilepsy | (Escayg, MacDonald, et al. 2000; Escayg et al. 2001; Inlow and Restifo 2004) | Epileptic seizures | (Ogiwara et al. 2007) | |
| Abat | Mental retardation; Autism; Schizophrenia | (Inlow and Restifo 2004: Barnby et al. 2005; Zhang et al. 2005) | NA | ||
| Kcnk2 | Autism | (Szatmari et al. 2007) | Kcnk2 deletion as an antidepression behavioral phenotype | (Heurteaux et al. 2006) | |
| Others | Dcx | Epilepsy; Mental retardation | (Reiner et al. 2006) | Deficient interneuron migration. | (Friocourt et al. 2007) |
| Man2a1 | Autism | (Szatmari et al. 2007) | NA | ||
| Nr2f2 | Autism | (Szatmari et al. 2007) | Defective tangential cell migration | (Tripodi et al. 2004) | |
| Shank3 | Autism | (Durand et al. 2007; Szatmari et al. 2007) | NA | ||
| Sez6l2 | Autism | (Szatmari et al. 2007) | NA | ||
| Dpp6 | Autism | (Szatmari et al. 2007) | NA | ||
| Centg2 | Autism | (Szatmari et al. 2007) (Wassink et al. 2005) | NA | ||
| Dtna | Autism | (Szatmari et al. 2007) | NA | ||