Fig. 1.

Body weights of Chow vs. high-fat diet (HFD) mice. A: 12-wk-old male C57BL/6 were fed either chow (n = 13) or HFD (n = 16) for 4 wk and body weights were recorded. B: Chow and HFD mice were subsequently subdivided into 4 groups: chow-no exercise (n = 6), chow-exercise (n = 7), HFD-no exercise (n = 8), and HFD-exercise (n = 8), and body weights were monitored for an additional 6 wk. Mice were housed individually, and running wheels were provided for exercise groups. #P < 0.05 vs. Chow; *P < 0.05 vs. HFD-Exercise; +P < 0.05 vs. Chow-Exercise.