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Attenuation of cocaine self-administration by MPEP pretreatment for ≥ 5 consecutive sessions. Data are means (± SEM) for the last three sessions at each condition in each of four monkeys. The cocaine dose response function following vehicle pretreatment is the average dose-response function for only those monkeys that had received MPEP pretreatment. Asterisks indicate significant reductions in cocaine self-administration after MPEP pretreatment compared to vehicle pretreatment.
