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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Cancer Res. 2008 Aug 1;68(15):6136–6144. doi: 10.1158/0008-5472.CAN-08-0464

Figure 1. MUC1 blocks death receptor-induced activation of caspase-8 and apoptosis.

Figure 1

A. BC-1 cells were infected with lentiviruses expressing the CsiRNA, MUC1siRNA#1 or MUC1siRNA#2. Lysates from the indicated clones were immunoblotted with anti-MUC1-C and anti-β-actin. B. The indicated BC-1 cell clones were treated with 50 ng/ml FasL for 8 h. Lysates were immunoblotted with the indicated antibodies. C. The indicated BC-1 cells were treated with 50 ng/ml FasL for 24 h and then analyzed by FACS for sub-G1 DNA content. D. The results obtained with the indicated BC-1 cells left untreated (open bars) or treated with FasL (solid bars) are expressed as the percentage apoptosis (mean±SD for three experiments).