Fig. 1.

Methylation in bladder samples at nine different loci using quantitative methylation-sensitive real-time PCR and shown as percent of a fully methylated reference (PMR), with PMR > 10% in grey, PMR ≤ 10% in black, and unavailable data in white. A Ten normal urothelium samples from cancer-free bladders were obtained during prostatectomies from age-matched patients. Forty-six matched sets of bladder tumor tissue and corresponding tissue were obtained during cystectomies. B Methylation data for 342 bladder cancer samples from paraffin-embedded tissues.