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. 2008 Jul 10;295(3):G470–G478. doi: 10.1152/ajpgi.90262.2008

Fig. 7.

Fig. 7.

Acid perfusion induces MEK1/2 phosphorylation on serines 217/222 in esophageal squamous epithelium of patients with GERD with and without Barrett's esophagus in vivo. A: representative Western blot demonstrating MEK1/2 phosphorylation and total MEK1/2 expression before and after esophageal acid perfusion. B: MEK1/2 phosphorylation relative to total MEK1/2 increases significantly following acid perfusion in esophageal squamous epithelium of patients with GERD with and without Barrett's esophagus (*P < 0.05). The bar graphs show the mean ± SE of esophageal squamous epithelial biopsies from 7 patients with GERD with Barrett's esophagus and 5 patients with GERD without Barrett's esophagus before and after acid perfusion.