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. 2008 Jul 10;295(3):G470–G478. doi: 10.1152/ajpgi.90262.2008

Fig. 8.

Fig. 8.

Acid perfusion induces ERK1/2 phosphorylation in esophageal squamous epithelium in patients who have GERD without Barrett's esophagus. A: representative Western blot demonstrating ERK1/2 phosphorylation before and after acid perfusion. B: ERK 1/2 phosphorylation relative to total ERK 1/2 increased significantly following acid exposure in esophageal squamous epithelium from patients who had GERD without Barrett's esophagus but not in those with Barrett's esophagus (*P < 0.05). The bar graphs show the mean ± SE of squamous epithelial biopsies from 7 patients with GERD with Barrett's esophagus and 5 patients with GERD without Barrett's esophagus before and after acid perfusion.