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. 2008 Jul 3;295(3):G431–G441. doi: 10.1152/ajpgi.90283.2008

Fig. 4.

Fig. 4.

H. pylori stimulates uPA, but not uPAR, or PAI-luc through a CagE-dependent mechanism. A: H. pylori [16 h, multiplicity of infection (MOI) 1:150] stimulates expression of uPA-luc that is abolished by deletion of the cagE but not cagA and vacA virulence factors. B and C: H. pylori also stimulates expression of PAI-luc and uPAR-luc, respectively, but this is not decreased by deletion of the cagE, cagA, or vacA virulence factors; n = 3–15, P < 0.05. (*control vs. wild-type H. pylori; **wild-type H. pylori vs. cagE-null mutant). wt, wild-type.