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uPA acts through heparin-binding EGF (HB-EGF) to stimulate epithelial cell proliferation. A: uPA (500 ng/ml)-stimulated BrdU incorporation was inhibited by neutralizing Ab to the EGF receptor (EGF-R) (2 μg/ml) and by receptor tyrosine kinase inhibitor (Inh) AG1478 (2 ng/ml). B: uPA-stimulated BrdU incorporation was also inhibited by neutralizing Ab to HB-EGF (5 μg/ml) and by the mutant diphtheria toxin CRM197 (5 μg/ml); n = 3–4, *P < 0.05, ANOVA.
