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ROK inhibition diminishes ET-1-mediated vasoconstriction in endothelium-intact pulmonary arteries from CH rats. Vascular reactivity (A and B) and changes in vessel wall [Ca2+]i to ET-1 (10−12 to 10−7 M; C and D) in the presence of Y-27632 (10 μM) in arteries from control (n = 6; A and C) and CH (n = 6; B and D) rats. Values are means ± SE. *P ≤ 0.05 vs. control group. #P ≤ 0.05 vs. CH vehicle group. Vehicle groups are the same as those shown in Fig. 1.
