Fig. 8.
Reactive oxygen species (ROS) generation contributes to ET-1-induced pulmonary VSM Ca2+ sensitization following CH. Percent vasoconstriction (percent baseline ID) to ET-1 (10−10 to 10−7 M) in isolated, permeabilized, endothelium-disrupted small pulmonary arteries from control (A) and CH (B) rats in the presence of tiron (10 mM; n = 4 per group). Values are means ± SE. *P ≤ 0.05 vs. control group. #P ≤ 0.05 vs. corresponding vehicle group. For purposes of illustration, the same vehicle groups are used as those shown in Fig. 3.