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Unique characteristics of animal species relevant to modeling lung injury
| Animal | % Identity with Human TLR4 HVR | Pulmonary Intravascular Macrophages | LPS Sensitivity | Nitric Oxide Production |
|---|---|---|---|---|
| Human | 100% | No | Intermediate | + |
| NHP | 95% | No | Intermediate | + |
| Pig | ND | Yes | High | ++ |
| Dog | ND | No | Low | ++ |
| Sheep | ND | Yes | High | ++ |
| Rabbit | 57% | No | Intermediate | ++ |
| Rat | 48% | No | Low | +++ |
| Mouse | 48% | No | Low | +++ |
HVR, hypervariable region of TLR4; NH, nonhuman primate; ND, not determined.
