Table 4.
Association results for SNPs with P < 0.01
| SNP | Chromosomal Region | Genetic Location, cM | Torque-Velocity Phenotype | LOD |
Likelihood-Ratio Test |
Analysis of Variance
|
||||
|---|---|---|---|---|---|---|---|---|---|---|
| Allele | Allele Effect Size | P Value | Carriers, n | Noncarriers, n | P Value | |||||
| rs1479371 | 3q12.3 | 113.38 | ratio flexion | 0.692 | G | −4.896 | 0.00031 | 61.7±0.9 (271) | 64.2±6.1 (10) | 0.701 |
| rs765695 | 3q24 | 151.04 | ratio extension | 0.127 | G | −2.339 | 0.0041 | 54.4±0.8 (234) | 58.2±1.6 (47) | 0.042 |
| rs1321834 | 6q13 | 86.07 | slope flexion | 0.379 | G | −1.712 | 0.0041 | −23.2±0.5 (270) | −21.2±1.4 (11) | 0.182 |
| rs1321834 | 6q13 | 86.07 | ratio extension | 1.011 | G | −3.380 | 0.00071 | 54.8±0.7 (270) | 63.5±2.4 (11) | 0.012 |
| rs1545963 | 13q21.31 | 59.33 | slope flexion | 0.008 | G | +1.337 | 0.0038 | −22.8±0.5 (241) | −25.6±0.7 (40) | 0.00022 |
Values are means ± SE.
1
G carriers vs. CC;
2
G carriers vs. AA; C carriers vs. AA; A carriers vs. CC. A carriers vs. GG. Genotype frequencies are in Hardy-Weinberg equilibrium (P > 0.01).