Fig. 10.

Ultrastructure of fibrotic interstitial changes in vasa recta areas of inner stripe in the kidneys of high-dose l-NMMA-treated mice. A: vas rectum (center) with mild interstitial fibrosis and matrix expansion as indicated by insets in higher magnification (B and C). B: accumulations of collagen I and amorphous matrix components between fenestrated capillary endothelium (right) and fibroblast extension. C: similar, but more abundant matrix accumulation. D: extended interstitium between tubular epithelia and a capillary showing a lipofuscin-laden interstitial cell as indicated by the inset in higher magnification (E). E: lipofuscin granules are represented by dense heterolysosomal residual bodies.