Endostatin staining for immunoreactivity. Immunoperoxidase staining of control (A, C, E, and G) and long-term, high dose l-NMMA-treated animals (B, D, F, and H) show an interstitial staining pattern in the cortex around the glomerular capsule (A and B), outer stripe proximal tubule segments (C and D), in the inner stripe interbundle region (E and F), and in the vascular bundles (G and H). Counterstaining was done with hematoxylin. Original magnification ×1,000.