Fig. 7.
Effect of glivec on ATP-induced inward current. A: continuous recording of membrane current with repeated exposures to 20 μM ATP. The preparation was exposed to 20 μM glivec during the second and third exposures to ATP. Before the second exposure to ATP a cell pair was formed at the arrow. Vh, −60 mV. B: percent increase in membrane currents to 100 μM ATP on formation of cell pairs under control conditions, during exposure to DMSO (0.1% vol/vol), during exposure to glivec (5–30 μM), and after removal of glivec. The final data set was corrected for run-down of the response (see text for details). *P < 0.05 with respect to control.