Table 1.
Protocol of different measured variables obtained from guinea pig preparations used in the current study, as a well as a qualitative description of the results
|
Guinea Pig (Normal) |
||||
|---|---|---|---|---|
| Isolated Myofibroblasts, Intracellular Ca2+/Membrane Current Transients | Cell Pairs, Intracellular Ca2+/Membrane Current Transients | Muscle Strip with Mucosa, Isometric Tension | Muscle Strip No. Mucosa, Isometric Tension | |
| Control | Stable cells (n = 90) | Stable cells (n = 47) | SA (n=6) | Reduced SA (n = 6) |
| ATP/UTP | Transients generated (n = 75) | Transients augmented (n = 29) | SA (n=6) | No increase in SA (n = 6) |
| Low pH | Transients generated (n = 6) | Transients augmented (n = 6) | ||
| NO donors | Transients reduced (n = 4) | |||
| Capsaicin | Current transient reduced (n = 5) | |||
| Glivec | Augmentation abolished (n = 12) | |||
n, No. of repeat observations from separate preparations for each experiment; SA, spontaneous activity; NO, nitric oxide.