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Blocking the Na/H exchanger inhibits the increase in intracellular pH (pHi) induced by increasing luminal NaCl. When macula densa NaCl was switched from 10 to 80 mM, pHi increased from 7.1 ± 0.1 to 7.7 ± 0.2 (P < 0.01; n = 4). In the presence of dimethylamiloride, a Na/H exchanger inhibitor, NaCl-induced changes in pH were blocked.
