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Effect of pHi on superoxide production by the macular densa. pHi was clamped with a K+/H+ ionophore, nigericin, to equilibrate luminal pH and pHi. When pHi was raised from 7.0 to 7.8 without a change in NaCl concentration, superoxide production by the macula densa was increased significantly (P < 0.01; n = 5).
