Fig. 6.

Effect of oxidative stress on ANG II-induced MAP kinase activation in renal proximal tubules from C, BSO-, T-, and BSO+T-treated rats. A: renal proximal tubules were challenged with 10 pM ANG II for 10 min. B: renal proximal tubules from control rats were incubated with 1 μM Can or 10 μM UO126 (UO) followed by challenge with 10 pM ANG II for 10 min. Bands are representative Western blots and bars are means ± SE of 6–8 different experiments performed in triplicate. *P < 0.05 vs. basal. #P < 0.05 vs. BSO. $P < 0.05 vs. ANG II + UO. ΨP < 0.05 vs. ANG II + Can using 1-way ANOVA followed by post hoc Newman-Keuls multiple test.