Table 1.

Food and water intake, oxidative markers, and blood pressure in BSO- and T-treated rats

	C	BSO	T	BSO+T
Body wt, g	240.0±23.0	249.0±18.0	255.0±21.0	245.0±17.0*
Food intake, g/day	18.8±4.2	19.6±3.3	19.2±3.9	17.6±4.5
8-Isoprostane urine, pg/mg creatinine	0.91±0.02	1.31±0.02*	0.89±0.06†	1.0±0.04†
8-Isoprostane serum, fg/mg creatinine	39.3±3.1	54.0±4.2*	36.9±3.2†	42.3±5.3†
Malondialdehyde, pmol/mg protein	88.9±6.3	124.9±9.3*	83.9±7.6†	93.9±8.3†
Nitrotyrosine, arbitrary units	116.6±11.3	183.2±15.3*	110.9±8.9†	130.3±10.6†
Glutathione, nmol/mg protein	2.1±0.3	0.8±0.1*	2.4±0.3†	1.51±0.2*†‡
Superoxide dismutase, EU/mg protein	2.4±0.2	1.3±0.1*	2.5±0.3†	2.2±0.2†
Glomerular filtration rate, ml/min	1.49±0.14	1.44±0.2	1.55±0.17	1.52±0.22
Mean blood pressure, mmHg	102.6±4.3	127.7±6.2*	99.6±5.5†	109.3±6.6†

Data are means ± SE from 6–8 rats and were analyzed by ANOVA followed by post hoc Newman-Keuls multiple comparison test. C, control; BSO, l-buthionine-sulfoximine; T, tempol.

^*P < 0.05 vs. C.

^†P < 0.05 vs. BSO.

^‡P < 0.05 vs. T.