Figure 6.

Schematic representation of the interaction between 4.1R and Rch1. We propose a model similar to that of Xiao et al. (1997) for the interaction of 4.1R with Rch1. In that model, the positively charged 4.1R NLS KKKRER in exon 16 and the negatively charged motif EED in exon 5 of 4.1R interact with clusters of negatively charged and positively charged residues of Rch1, respectively. Amino acids responsible for electrostatic interactions between Rch1 and importin β are also displayed.