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Microcystin blocks the decline in the activity of wild-type NPR-A but not NPR-A-6E in vitro. Human 293 cells were transiently transfected with either the NPR-A (W.T., squares) or NPR-A-6E (6E, circles) expression constructs; 48 h later, crude membranes were prepared, and hormone-dependent guanylyl cyclase activity (ANP, ATP, and Mg2+-GTP) was determined for the indicated periods in the presence (filled symbols) or absence (open symbols) of 1 μM microcystin.
