FIG. 3.
Mean viral blip frequency (▪) and mean viral blip amplitude (•) ± the standard error in nonoverlapping subperiods of observations. The mean viral blip frequency and the mean viral blip amplitude do not vary significantly with the time of observation. The change in mean viral blip frequency was tested for significance (Pf) with nonparametric repeated-measures analysis of variance (Friedman test). The change in mean viral blip amplitude was tested for significance (PA) with the Kruskal-Wallis test. (a) Analysis restricted to patients that were observed more than 2 years from the third visit during the period of VL suppression (n = 63). Subintervals were fixed at 180 days (6 months), and the analysis was limited to the first 2 years (Pf = 0.17 and PA = 0.44). (b) Analysis restricted to patients that were observed more than 3 years from the third visit during the period of VL suppression (n = 30). Subintervals were fixed at 270 days (9 months), and the analysis was limited to the first three years (Pf = 0.44 and PA = 0.84). (c) Analysis restricted to patients observed more than 4 years from the third visit during the period of VL suppression (n = 10). Subintervals were fixed at 360 days (1 year), and the analysis was limited to the first four years (Pf = 0.08 and PA = 0.35).