Table 2.

Top-10 CNM clusters with highest p-values

	Cluster ID	P -value	GO Term	Term Freq. in Network	Term Freq. in Cluster	Cluster Size
Biological Process	15	2.10E-61	nuclear mrna splicing, via spliceosome	66	55	220
	17	5.00E-40	transposition, rna-mediated	33	19	22
	13	5.11E-31	rna elongation from rna polymerase ii promoter	53	51	919
	49	4.30E-25	ribosomal large subunit assembly and maintenance	39	34	549
	16	1.09E-23	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	13	13	75
	58	2.78E-22	microtubule nucleation	22	16	98
	53	7.86E-20	trna processing	14	8	10
	45	8.35E-18	negative regulation of gluconeogenesis	9	7	12
	56	3.15E-17	ubiquitin-dependent protein catabolic process via the multivesicular body pathway	13	11	91
	63	1.73E-13	mrna polyadenylation	17	13	241
Cellular Components	11	3.67E-66	mitochondrial large ribosomal subunit	43	41	107
	49	4.72E-42	cytosolic large ribosomal subunit	80	64	549
	17	5.00E-40	retrotransposon nucleocapsid	33	19	22
	58	1.28E-30	condensed nuclear chromosome kinetochore	30	22	98
	16	2.48E-24	anaphase-promoting complex	15	14	75
	20	1.58E-23	peroxisomal membrane	12	9	11
	37	9.63E-23	smc5-smc6 complex	8	8	11
	53	2.36E-22	ribonuclease mrp complex	9	8	10
	63	5.21E-18	mrna cleavage and polyadenylation specificity factor complex	14	14	241
	65	3.13E-15	alpha-1,6-mannosyltransferase complex	6	6	18
Molecular Functions	17	1.71E-26	rna binding	130	19	22
	58	2.34E-24	structural constituent of cytoskeleton	47	22	98
	53	2.36E-22	contributes_to ribonuclease mrp activity	9	8	10
	13	9.16E-19	dna-directed rna polymerase activity	31	30	919
	49	6.52E-17	snorna binding	21	20	549
	48	5.97E-13	contributes_to protein transporter activity	7	5	10
	30	1.24E-10	nad-independent histone deacetylase activity	4	4	15
	65	2.79E-10	contributes_to alpha-1,6-mannosyltransferase activity	4	4	18
	33	1.34E-09	endopeptidase activity	26	24	1408
	63	2.52E-09	contributes_to histone lysine n-methyltransferase activity (h3-k4 specific)	7	7	241